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Unlike the mutations in the Pit-1 and PROP-1 genes, which lead to multiple pituitary hormone deficiencies and anterior pituitary hypoplasia, mutations in the GHRH receptor leads to profound GH deficiency with anterior pituitary hypoplasia

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In the era of generative artificial intelligence (AI) capable of producing knowledge by integrating information from multiple levels and extracting generalizations of higher quality, adopting a single-level reductionist model, the biological one, condemns clinical research to remain in the stagnation of recent decades, in which progress has been lower than expected and not corresponding to the economic investments made

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